B: Radiobiology Intermediate Topics
The intermediate topics attempt to mirror the current curriculum. Due to a lot of shifting around these are still a work in progress. Let me know if you have any questions. You may find topics in the orphaned section of radiobiology, here.
R01: History of Radiobiology
- R01.1: Early Observations
- R01.2: History of the Therapeutic Ratio
- R01.3: Development of Fractionation
R02: Normal Cell Function
- R02.1: Normal Cell Structure (Advanced)
- R02.2: Structure of Eukaryotic Genes
- R02.3: Chromosome Packaging
- R02.4: DNA Replication
- R02.5: RNA Transcription & Translation
- R02.7: The Cell Cycle
R03: Mechanisms of Malignant Cell Transformation
R04: Tumour Growth
R05: Effect of Radiation on Cells
- R5.1: Variations In Cellular Radiation Sensitivity
- R5.2: Somatic and Gametic Cells
- R5.3: Chromosome Damage
- R5.4: DNA Damage and Repair
- R5.5: Mechanisms Of Cell Death
- R5.6: Predictive Assays
R06: DNA Repair
R07: Modelling of Radiation Effects
- R6.1: Random Nature Of Cell Kill
- R6.2: Generation Of Survival Curves
- R6.3: Factors Influencing Dose Response Curves
- R6.4: Cell Survival Curve Models
R08: Fractionation and the 5 R's
R09: Clinical use of the L/Q model and 𝜶/β ratio
R10: Radiation and Oxygen
- R9.1: The Oxygen Effect
- R9.2: Factors Influencing The Oxygen Effect
- R9.3: Tumour Hypoxia
- R9.4: Reoxygenation
- R9.5: Methods To Overcome Tumour Hypoxia
R11: Radiation Quality
R12: Dose Response for Tumours
R13: Normal Tissue Effects
- Pathophysiology and Mediators of Early Effects
- Early Effects in Normal Tissues
- Measurement of early toxicity
- Latency of Early Effects
- Effect of Time and Fractionation on Early Effects
- Pharmacological Modification of Early Effects
- Acute Radiation Syndromes
- Radiation and the Immune System
- Biological Dosimetry
- Rationale for Total Body Irradiation
- The Abscopal Effect
- Subacute Radiation Effects
- Pathophysiology and Mediators of late effects
- Late Effects in Normal Tissues <- Numerous subtopics awaiting completion
- Tissue Tolerance
- Measurement of late toxicity
- Latency and late effects
- Fractionation and late effects
- Cytokines involved in late effects
- Consequential Late Effects
- Deterministic and Stochastic Effects
- Radiation induced mutations <— Hereditary effects make more sense than more carcinogenesis repetition
- Low level radiation
R14: Radiation and the Foetus
R15: Quantification of Normal Tissue Effects
R16: Radiation Carcinogenesis
- Carcinogenesis after radiation exposure
- Carcinogenesis from in utero exposure
- Carcinogenesis from occupational, medical or military exposure
R17: Combination of Radiation with Other Therapies
- Sequencing of Radiation and Surgery
- Surgery and Clonagen Reduction
- Radiosensitisers
- Radioprotectors
- Combined Modality Treatment
- Hazards of Combined Modality Treatment
- Dose-Enhancement Factor