R4.5j: Tumour Promoting Inflammation
Certain autoimmune conditions, such as ulcerative colitis or Sjogren's syndrome, promote the development of malignancy in the afflicted organ. This is due to the carcinogenic effects of inflammation on the target organ.
Malignant tumours are frequently infiltrated by cells of the immune system. It is thought that the inflammation caused by this infiltration, rather than helping to overcome the tumour, may in fact help to promote further mutation within the malignancy. Cytokines released by inflammatory cells may also contribute to tumour proliferation.
Links
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Old R04: Advanced Cell Biology
- R4.1: Major Cell Cycle Regulators
- R4.2: Signal Transduction
- R4.3: Molecular Response to Ionising Radiation
- R4.4: Tumour Kinetics
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R4.5: Hallmarks of Cancer
- R4.5a: Self Sufficiency In Growth Signals
- R4.5b: Insensitivity To Growth Inhibition
- R4.5c: Resisting Cell Death
- R4.5d: Immortality
- R4.5e: Angiogenesis
- R4.5f: Invasion and Metastasis
- R4.5g: Deregulation of Cellular Energetics
- R4.5h: Immune Avoidance
- R4.5i: Genomic Instability
- R4.5j: Tumour Promoting Inflammation
- R4.6: In Vitro Features Of Transformed Cells
- R4.7: Mouse Models Of Tumour Initiation And Promotion