R5.4: DNA Damage and Repair

DNA is recognised as the principle target of radiotherapy in human cells. The processes by which DNA is damaged by radiation, the cellular response to that damage, is covered in the following sub topics.

Topics

• R5.4a: Types Of DNA Lesions
• R5.4b: Classes Of Damage
• R5.4c: Assays For DNA Damage And Repair
• R5.4d: DNA Damage Response
• R5.4e: DNA Damage Response Genes
• R5.4f: DNA Damage/Repair Syndromes

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Links

• R05: Effect of Radiation On Cells
  • R5.1: Variations In Cellular Radiation Sensitivity
  • R5.2: Somatic and Gametic Cells
  • R5.3: Chromosome Damage
  • R5.4: DNA Damage and Repair
  • R5.5: Mechanisms Of Cell Death
  • R5.6: Predictive Assays