The vulva has several glandular structures (Bartholin and Skene glands) that can cause malignancy. Anogenital glands that contain tissue closely resembling breast glandular tissue are also present within the vulva and may give rise to breast malignancies.
Bartholin Gland Adenocarcinoma
A rare malignancy that may resemble a Bartholin's cyst. Most are adenocarcinoma of squamous cell carcinoma.
Skene Gland Adenocarcinoma
Very, very rare tumour arising from the prostate homologue in women; these tumours may produce PSA.
Paget's Disease of the Vulva
Paget's disease of the vulva is an uncommon presentation where malignant cells grow within the epidermis, but do not breach the basement membrane. The malignant cells can be epithelial in origin, or may arise from the epithelium of the urethra (transitional cell type) or accessory glands (adenocarcinoma). It has a similar presentation
These tumours may mimic intraductal carcinoma of the breast, but present as a lump within the vulva.