Plasma cells are differentiated B-lymphocytes that are specialised in producing immunoglobulin. A plasma cell neoplasm is formed by the uncontrolled expansion of a single clone of these cells. The most commonly encountered malignancy is the plasma cell myeloma (or multiple myeloma), which by itself accounts for about 10-15% of haematological malignancy. Other important entities include:
- Monoclonal gammopathy of undetermined significance
- Solitary plasmacytoma
- Primary amyloidosis
Plasma Cell Myeloma
Epidemiology
Myeloma is an uncommon malignancy, accounting for 1% of all cancers and 10-15% of haematological tumours. It is slightly more common in men; it never occurs in children and most patients are aged over 50 (median age 70). There is an 4-fold increased of myeloma in first degree relatives with myeloma.
Aetiology
Although most patients have no identifiable cause, there is a suggestion that chronic exposure to occupational antigens or radiation may be a contributing factor.
Natural History
Myeloma is typically widespread at diagnosis.
Clinical Features
Aetiology and Pathogenesis
Individual causative factors
Pathogenesis
Natural History
Precursor lesions
Modes of spread
Clinical Presentation
Symptoms
Signs
Blood Findings
Imaging Findings
Tumour/Normal Tissue Features
Laboratory Diagnosis
- macroscopic, microscopic, architecture, grading, growth patterns, immunohistochemistry, molecular techniques, serum markers
Staging / Classification
TNM or other staging system if relevant